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MBRS-SCORE Faculty Research
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MBRS-SCORE Faculty Research
Dr.
Donna Barnes (Women's Studies Dept.)
Dr.
Donald Gailey (Dept. of Biology)
Dr.
Michael Hedrick (Dept. of Biology)
Dr. Chul Kim (Department of Biology)
Dr. Maria Gallegos (Department of Biology)
Dr. Claudia Uhde-Stone (Department of Biology)
Dr. Donna B. Barnes (Women's Studies Program)
The current study, is a Ten Year Follow -Up of the 60 HIV positive women who participated in a study of their reproductive decision making process. The study explores the social contexts that influence HIV positive women’s reproductive decision-making, mothering, and living experiences. Two hour face-to-face interviews are conducted with the 60 women from Oakland, California (n=30) and from Rochester, New York (n=30). Results are analyzed using qualitative grounded theory methodology. This ten year follow up study will provide empirical information on HIV positive women’s unique experiences, in order to design more effective and appropriate health initiatives and interventions.
- Research Presentations: (Click on links below)
- 5. Women's Reproductive Decision-Making Process and Providers' Participation presented at the Second International AIDS Society Conference on HIV Pathogenesis and Treatment, Paris, France (July 13-16th, 2003).
donna.barnes@csueastbayedu
The general interest of the lab is the genetic basis of sex and sex behavior. The current focus is the fruitless sex determination gene in the fruit fly Drosophila melanogast. Dr. Gailey's newest research project is titled "Sex Determination and the fruitless gene in Tribolium".
Dr. Michael Hedrick (Professor, Dept. of Biological Sciences)
Dr. Hedrick's newest research project is titled "Cellular Mechanisms for Breathing and Hypoxia Tolerance".
Education:
B.S. Biology, Lewis and Clark College, 1980
M.S. Biology, Portland State University, 1985
Ph.D. Zoology, University of British Columbia, 1991
Post-doctoral Fellow, University of Wisconsin, 1991-1994
Research Interests: Respiratory Neurobiology and Cardiovascular Physiology
My major interest is in the development and regulation of respiratory rhythm generation, particularly in amphibians. My laboratory uses an in vitro brainstem preparation from bullfrogs (Rana catesbeiana) to investigate how respiratory rhythm is generated and regulated during development. The in vitro brainstem model is particularly useful for examining the control of respiratory rhythm at the cellular and network level. A unique feature of this model is that the gamut of developmental stages, from tadpole to adult, can be examined under identical experimental conditions, which allows us to gain better insight into the mechanisms that regulate respiratory rhythm during development. The results my students and I have obtained using this model indicate there are significant changes in the regulation of respiratory rhythm generation and that many of these changes take place at the onset of metamorphosis. Future plans in this area of research are to locate specific neuroanatomical brainstem areas that contribute to rhythm generation, record and characterize neurons from these anatomical locations, examine the role of pacemaker and network contributions to rhythm generation, examine the role of oxygen-sensing mechanisms in the respiratory response to hypoxia, and examine the role of intracellular calcium as a neuroprotective signaling mechanism in anoxia.
Recent Presentations:
Development of respiratory rhythm generation in amphibians. American Physiological Society. Virginia Beach, VA. October, 2006.
Glutamateric regulation of respiratory rhythm generation during development in the bullfrog (Rana catesbeiana). Society for Experimental Biology. Canterbury, England. April, 2006.
Neuromodulation of the dual respiratory oscillators in the developing amphibian brainstem. Experimental Biology. San Diego, CA. April, 2005.
Nitric oxide and the development of the respiratory central pattern generator in amphibians. Society for Experimental Biology. Capri, Italy. September, 2004.
Development of the respiratory response to anoxia in the isolated bullfrog brainstem. Experimental Biology. Washington , DC . April, 2004.
Role of ATP-sensitive K + channels in hypoxia-induced respiratory responses in isolated brainstem preparations from larval and adult bullfrogs. International Society for Autonomic Neuroscience. Calgary, AB. August, 2003.
MBRS-Related Publications:
Winmill, R.E. and M.S. Hedrick (2003). Gap junction blockade with carbenoxolone differentially affects fictive breathing in larval and adult bullfrogs. Respir. Physiol. Neurobiol. 138: 239-251.
Winmill, R.E. and M.S. Hedrick (2003). Developmental changes in the modulation of respiratory rhythm generation by extracellular K + in the isolated bullfrog brainstem. J. Neurobiol. 55: 278-287.
Hedrick, M.S. and R.E. Winmill (2003). Excitatory and inhibitory effects of tricaine (MS-222) on fictive breathing in the bullfrog brainstem. Am. J. Physiol. 284: R405-R412.
Morales, R.D. and M.S. Hedrick (2002). Temperature and pH/CO 2 modulate respiratory activity in the isolated brainstem of the bullfrog (Rana catesbeiana). Comp. Biochem. Physiol. 132A: 477-487.
Broch, L., R.D. Morales, A.V. Sandoval and M.S. Hedrick (2002). Regulation of the respiratory central pattern generator by chloride-dependent inhibition during development in the bullfrog (Rana catesbeiana). J. Exp. Biol. 205: 1161-1169.
Hedrick, M.S., R.D. Morales, J.M. Parker and J.L.H. Pacheco (1998). Nitric oxide modulates respiratory-related neural activity in the isolated brainstem of the bullfrog. Neurosci. Lett. 251: 81-84.
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Dr. Maria Gallegos (Dept. of Biology)
Dr. Claudia Uhde-Stone (Department of Biology)
The research in my laboratory focuses on plant adaptation to nutrient stress, particularly to phosphorus and nitrogen deficiency. We are working with white lupin (Lupinus albus L.), a legume that is especially well adapted to nutrient-deficient soils. A goal of our research is to learn more about the molecular and biochemical adaptations to nutrient deficiencies displayed by plants. This is important because nitrogen and phosphorus are the two most limiting nutrients for plant growth and development on much of the world’s arable land.
Recent presentations:White R., McLaughlin D., Jobrack A., and C. Uhde-Stone. Functional analysis of a MATE gene in cluster roots of white lupin. 2 nd Pan American Plant Membrane Biology Workshop, South Padre Island, Texas, May 2006.
Uhde-Stone C. Plant adaptation to phosphorus deficiency: A functional genomics project in white lupin. San Jose State University, Department of Biological Sciences Seminar, March 2006.
Frey, S. and Uhde -Stone, C. A biomechanical model of Arabidopsis thaliana root hair growth. California State University East Bay, Department of Mathematics and Computer Science Seminar, May 2006.
Recent publications:
Uhde-Stone, C., Liu J., Zinn, K. E., D.L. Allan, and C.P. Vance. 2005.
Transgenic proteoid roots of white lupin: a vehicle for characterizing and silencing root genes involved in adaptation to P stress. The Plant Journal. 44: 840-853
Liu, J., Yamagishi, M., Uhde-Stone, C., Bucciarelli, B., Samac, D.A., Allan, D., and C.P. Vance, 2005. Shoot signals and molecular regulation of P-deficiency induced genes in cluster roots of white lupin. In: Plant Nutrition for Food Security, Human Health and Environmental Protection. Tsinghua University Press. p. 94-96
Uhde-Stone, C, Zinn, K.E., Ramirez-Yánez, M., Li, A., Vance C.P. and D.L. Allan. 2003. Nylon filter arrays reveal differential gene expression in proteoid roots of white lupin in response to P deficiency. Plant Physiology 131:1064-1079.
Vance, C.P., Uhde-Stone, C., and D.L. Allan. 2003. Phosphorus acquisition and use: critical adaptations by plants for securing a nonrenewable resource. Tansley Review. New Phytologist 157:423-447.
Uhde-Stone, C., Gilbert, G., Johnson, J. M.-F, Litjens, R., Zinn, K.E., Temple, S.J., Vance, C.P. and D.L. Allan. 2003. Acclimation of white lupin to phosphorus deficiency involves enhanced expression of genes related to organic acid metabolism. Plant and Soil 248:99-116.
I have recently proposed research to investigate developmental differences in the effects of ethanol on anxiety and examine the role of GABA-A receptor activity in ethanol-induced changes in anxiety in adolescent and adult mice. Initial experiments will characterize the anxiety-reducing effects of acute ethanol exposure in adolescent and adult mice, and the ability of the GABA-A receptor antagonist, picrotoxin, to attenuate or block ethanol’s effects.
Further experiments will characterize the anxiety-increasing effects of ethanol withdrawal in adolescent and adult mice and the ability of benzodiazepines to attenuate those effects. It is hoped that a better understanding of ethanol’s effects in adolescence will aid in the development of more effective prevention strategies or treatment for
human adolescents.Research and Professional Experience
2004-Present Assistant Professor, Department of Psychology, California State University East Bay
2003-2004 Research Associate, Department of Behavioral Neuroscience, School of Medicine, Oregon Health & Science University, Portland, OR
2001-2003 Postdoctoral Research Fellow, Department of Behavioral Neuroscience, School of Medicine, Oregon Health & Science University, Portland, OR - I examined the effects of maternal environment on alcohol responses in adult animals, the effects of topiramate on alcohol consumption, and the role of allopregnanolone on alcohol-induced conditioned place preference.
2000-2001 Postdoctoral Research Fellow, Alcohol and Drug Abuse Research Center, McLean Hospital – Harvard Medical School, Boston, MA - I investigated genotype-mediated differences in cocaine-induced locomotor activity and evaluated cocaine-maintained operant responding in mice lacking specific dopamine receptor subtypes.
1993-2000 Graduate Student (Masters of Arts, 1993-1995; Doctor of Philosophy, 1995-2000), Department of Psychology, University of British Columbia - I studied the effects of prenatal alcohol exposure and postnatal handling on cognition/behavior and hypothalamic-pituitary-adrenal hormone responses in rats (PhD). I also examined the effects of prenatal alcohol exposure and stress in adulthood on the endocrine and immune system (MA).
1991 Bachelor of Arts in Psychology and English, University of Wisconsin-Madison